Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

Andrea Flesken-Nikitin, Chang-Il Hwang, Chieh-Yang Cheng, Tatyana V. Michurina, Grigori Enikolopov and Alexander Yu. Nikitin ()
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Andrea Flesken-Nikitin: Cornell University
Chang-Il Hwang: Cornell University
Chieh-Yang Cheng: Cornell University
Tatyana V. Michurina: Cold Spring Harbor Laboratory
Grigori Enikolopov: Cold Spring Harbor Laboratory
Alexander Yu. Nikitin: Cornell University

Nature, 2013, vol. 495, issue 7440, 241-245

Abstract: The hilum (a transitional region) of the mouse ovary is identified as a stem cell niche of the ovarian surface epithelium, and its cells are prone to malignant transformation after inactivation of common tumour suppressor genes, suggesting that they may be the origin of ovarian carcinoma.

Date: 2013
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DOI: 10.1038/nature11979

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