Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

V. Stalin Raj, Huihui Mou, Saskia L. Smits, Dick H. W. Dekkers, Marcel A. Müller, Ronald Dijkman, Doreen Muth, Jeroen A. A. Demmers, Ali Zaki, Ron A. M. Fouchier, Volker Thiel, Christian Drosten, Peter J. M. Rottier, Albert D. M. E. Osterhaus, Berend Jan Bosch () and Bart L. Haagmans ()
Additional contact information
V. Stalin Raj: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Huihui Mou: Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands
Saskia L. Smits: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Dick H. W. Dekkers: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Marcel A. Müller: Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany
Ronald Dijkman: Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
Doreen Muth: Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany
Jeroen A. A. Demmers: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Ali Zaki: Virology Laboratory, Dr Soliman Fakeeh Hospital
Ron A. M. Fouchier: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Volker Thiel: Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
Christian Drosten: Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany
Peter J. M. Rottier: Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands
Albert D. M. E. Osterhaus: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Berend Jan Bosch: Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands
Bart L. Haagmans: Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands

Nature, 2013, vol. 495, issue 7440, 251-254

Abstract: Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.

Date: 2013
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DOI: 10.1038/nature12005

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