NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

Yael Costa, Junjun Ding, Thorold W. Theunissen, Francesco Faiola, Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, José C. R. Silva () and Jianlong Wang ()
Additional contact information
Yael Costa: Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Junjun Ding: Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine
Thorold W. Theunissen: Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Francesco Faiola: Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine
Timothy A. Hore: Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
Pavel V. Shliaha: Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Miguel Fidalgo: Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine
Arven Saunders: Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine
Moyra Lawrence: Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Sabine Dietmann: Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Satyabrata Das: and Program in Molecular and Cellular Biology, University of Iowa
Dana N. Levasseur: and Program in Molecular and Cellular Biology, University of Iowa
Zhe Li: Indiana University
Mingjiang Xu: Indiana University
Wolf Reik: Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
José C. R. Silva: Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Jianlong Wang: Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine

Nature, 2013, vol. 495, issue 7441, 370-374

Abstract: The authors show that the pluripotency factor NANOG interacts with TET1 and TET2 methylcytosine hydroxylases, and that the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine enhances the efficiency of somatic cell reprogramming in a NANOG-dependent manner.

Date: 2013
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DOI: 10.1038/nature11925

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