Differential stem- and progenitor-cell trafficking by prostaglandin E2

Jonathan Hoggatt, Khalid S. Mohammad, Pratibha Singh, Amber F. Hoggatt, Brahmananda R. Chitteti, Jennifer M. Speth, Peirong Hu, Bradley A. Poteat, Kayla N. Stilger, Francesca Ferraro, Lev Silberstein, Frankie K. Wong, Sherif S. Farag, Magdalena Czader, Ginger L. Milne, Richard M. Breyer, Carlos H. Serezani, David T. Scadden, Theresa A. Guise, Edward F. Srour and Louis M. Pelus ()
Additional contact information
Jonathan Hoggatt: Microbiology and Immunology, Indiana University School of Medicine
Khalid S. Mohammad: Medicine/Endocrinology, Indiana University School of Medicine
Pratibha Singh: Microbiology and Immunology, Indiana University School of Medicine
Amber F. Hoggatt: Microbiology and Immunology, Indiana University School of Medicine
Brahmananda R. Chitteti: Indiana University School of Medicine
Jennifer M. Speth: Microbiology and Immunology, Indiana University School of Medicine
Peirong Hu: Microbiology and Immunology, Indiana University School of Medicine
Bradley A. Poteat: Indiana University School of Medicine
Kayla N. Stilger: Microbiology and Immunology, Indiana University School of Medicine
Francesca Ferraro: Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital
Lev Silberstein: Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital
Frankie K. Wong: Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital
Sherif S. Farag: Indiana University School of Medicine
Magdalena Czader: Pathology and Laboratory Medicine, Indiana University School of Medicine
Ginger L. Milne: Eicosanoid Core Laboratory, Vanderbilt University
Richard M. Breyer: Vanderbilt University
Carlos H. Serezani: Microbiology and Immunology, Indiana University School of Medicine
David T. Scadden: Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute/Harvard Medical School/Center for Regenerative Medicine, Massachusetts General Hospital
Theresa A. Guise: Medicine/Endocrinology, Indiana University School of Medicine
Edward F. Srour: Microbiology and Immunology, Indiana University School of Medicine
Louis M. Pelus: Microbiology and Immunology, Indiana University School of Medicine

Nature, 2013, vol. 495, issue 7441, 365-369

Abstract: Endogenous prostaglandin E2 (PGE2) is a potent regulator of haematopoietic stem cell (HSC) retention in the bone marrow; inhibition of endogenous PGE2 signalling by non-steroidal anti-inflammatory drugs results in enhanced HSC and haematopoietic progenitor cell mobility via E-prostanoid 4 (EP4) receptor antagonism.

Date: 2013
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DOI: 10.1038/nature11929

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