Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

Tim J. Schulz, Ping Huang, Tian Lian Huang, Ruidan Xue, Lindsay E. McDougall, Kristy L. Townsend, Aaron M. Cypess, Yuji Mishina, Emanuela Gussoni and Yu-Hua Tseng ()
Additional contact information
Tim J. Schulz: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Ping Huang: Boston Children’s Hospital, Harvard Medical School
Tian Lian Huang: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Ruidan Xue: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Lindsay E. McDougall: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Kristy L. Townsend: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Aaron M. Cypess: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Yuji Mishina: School of Dentistry, University of Michigan
Emanuela Gussoni: Boston Children’s Hospital, Harvard Medical School
Yu-Hua Tseng: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School

Nature, 2013, vol. 495, issue 7441, 379-383

Abstract: A shortage of constitutive brown adipose tissue is shown to result when brown adipogenic progenitor cells lack a type of BMP receptor; however, this leads to an increase in sympathetic input to white adipose tissue and a compensatory browning of white fat depots.

Date: 2013
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DOI: 10.1038/nature11943

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