Multidomain integration in the structure of the HNF-4α nuclear receptor complex

Vikas Chandra, Pengxiang Huang, Nalini Potluri, Dalei Wu, Youngchang Kim and Fraydoon Rastinejad ()
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Vikas Chandra: Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute
Pengxiang Huang: Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute
Nalini Potluri: Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute
Dalei Wu: Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute
Youngchang Kim: Structural Biology Center, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA
Fraydoon Rastinejad: Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute

Nature, 2013, vol. 495, issue 7441, 394-398

Abstract: The crystal structure of the transcriptional regulator HNF-4α bound to its DNA response element and coactivator-derived peptides is described, revealing a multidomain convergence centre that serves as an allosteric transmission system.

Date: 2013
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DOI: 10.1038/nature11966

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