Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen (), Trine I. Jensen, Bettina H. Clausen, Jesper B. Bramsen, Bente Finsen, Christian K. Damgaard and Jørgen Kjems ()
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Thomas B. Hansen: Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark
Trine I. Jensen: Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark
Bettina H. Clausen: Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløwsvej 25, 5000C, Odense, Denmark
Jesper B. Bramsen: Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark
Bente Finsen: Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløwsvej 25, 5000C, Odense, Denmark
Christian K. Damgaard: Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark
Jørgen Kjems: Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark

Nature, 2013, vol. 495, issue 7441, 384-388

Abstract: A natural circular RNA termed ciRS-7 is shown to function as a negative regulator of microRNA; ciRS-7 acts as an efficient sponge for the microRNA miR-7, and is resistant to the usual microRNA-mediated degradation pathway of exonucleolytic RNA decay.

Date: 2013
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DOI: 10.1038/nature11993

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