A syringe-like injection mechanism in Photorhabdus luminescens toxins

Christos Gatsogiannis, Alexander E. Lang, Dominic Meusch, Vanda Pfaumann, Oliver Hofnagel, Roland Benz, Klaus Aktories and Stefan Raunser ()
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Christos Gatsogiannis: Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany
Alexander E. Lang: Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany
Dominic Meusch: Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany
Vanda Pfaumann: Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany
Oliver Hofnagel: Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany
Roland Benz: School of Engineering and Science, Jacobs University Bremen, Campusring 1, 28759 Bremen, Germany
Klaus Aktories: Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany
Stefan Raunser: Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany

Nature, 2013, vol. 495, issue 7442, 520-523

Abstract: The TcA component of Photorhabdus luminescens ABC-type toxin complexes forms a transmembrane pore and injects TcC, the functional component of the toxin, into the target cell by means of a syringe-like mechanism.

Date: 2013
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DOI: 10.1038/nature11987

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