Conformational biosensors reveal GPCR signalling from endosomes

Roshanak Irannejad, Jin C. Tomshine, Jon R. Tomshine, Michael Chevalier, Jacob P. Mahoney, Jan Steyaert, Søren G. F. Rasmussen, Roger K. Sunahara, Hana El-Samad, Bo Huang and Mark von Zastrow ()
Additional contact information
Roshanak Irannejad: University of California
Jin C. Tomshine: University of California
Jon R. Tomshine: University of California
Michael Chevalier: University of California
Jacob P. Mahoney: University of Michigan Medical School
Jan Steyaert: Vrije Universiteit Brussel, B-1050 Brussels, Belgium
Søren G. F. Rasmussen: The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
Roger K. Sunahara: University of Michigan Medical School
Hana El-Samad: University of California
Bo Huang: University of California
Mark von Zastrow: University of California

Nature, 2013, vol. 495, issue 7442, 534-538

Abstract: Conformation-specific antibodies capable of monitoring the activation state of a G-protein-coupled seven-transmembrane receptor, the β2-adrenoceptor, reveals receptor and G-protein activation not only in the plasma membrane, but also in the endosome.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (8)

Downloads: (external link)
https://www.nature.com/articles/nature12000 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:495:y:2013:i:7442:d:10.1038_nature12000

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12000

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().