A metabolic metamorphosis
Abigail S. Krall () and
Heather R. Christofk ()
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Abigail S. Krall: University of California, Los Angeles, Los Angeles, California 90095, USA.
Heather R. Christofk: University of California, Los Angeles, Los Angeles, California 90095, USA.
Nature, 2013, vol. 496, issue 7443, 38-40
Abstract:
Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.
Date: 2013
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DOI: 10.1038/496038a
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