A solution to release twisted DNA during chromosome replication by coupled DNA polymerases

Isabel Kurth, Roxana E. Georgescu and Mike E. O'Donnell ()
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Isabel Kurth: The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA
Roxana E. Georgescu: The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA
Mike E. O'Donnell: The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA

Nature, 2013, vol. 496, issue 7443, 119-122

Abstract: During chromosome replication, coupled polymerases introduce topological changes that cause lower processivity and transient lagging-strand polymerase dissociation from DNA.

Date: 2013
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DOI: 10.1038/nature11988

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