Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Wei-chen Chang, Mishtu Dey, Pinghua Liu, Steven O. Mansoorabadi, Sung-Ju Moon, Zongbao K. Zhao, Catherine L. Drennan and Hung-wen Liu ()
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Wei-chen Chang: College of Pharmacy, University of Texas at Austin
Mishtu Dey: Massachusetts Institute of Technology
Pinghua Liu: College of Pharmacy, University of Texas at Austin
Steven O. Mansoorabadi: College of Pharmacy, University of Texas at Austin
Sung-Ju Moon: College of Pharmacy, University of Texas at Austin
Zongbao K. Zhao: College of Pharmacy, University of Texas at Austin
Catherine L. Drennan: Massachusetts Institute of Technology
Hung-wen Liu: College of Pharmacy, University of Texas at Austin

Nature, 2013, vol. 496, issue 7443, 114-118

Abstract: The non-haem-iron-dependent enzyme HppE catalyses the final step in the biosynthesis of fosfomycin, a broad-spectrum, clinically useful antibiotic; here it is shown that HppE can also catalyse a 1,2-phosphono-migration reaction, previously undocumented for any enzyme.

Date: 2013
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DOI: 10.1038/nature11998

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