The emergence of functional microcircuits in visual cortex

Ho Ko, Lee Cossell, Chiara Baragli, Jan Antolik, Claudia Clopath, Sonja B. Hofer () and Thomas D. Mrsic-Flogel ()
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Ho Ko: Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Lee Cossell: Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Chiara Baragli: Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Jan Antolik: Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Claudia Clopath: Center for Theoretical Neuroscience, Columbia University, 1051 Riverside Drive, Unit 87 Kolb Research Annex, New York, New York 10032, USA
Sonja B. Hofer: Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Thomas D. Mrsic-Flogel: Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK

Nature, 2013, vol. 496, issue 7443, 96-100

Abstract: A study of mouse visual cortex relating patterns of excitatory synaptic connectivity to visual response properties of neighbouring neurons shows that, after eye opening, local connectivity reorganizes extensively: more connections form selectively between neurons with similar visual responses and connections are eliminated between visually unresponsive neurons, but the overall connectivity rate does not change.

Date: 2013
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DOI: 10.1038/nature12015

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