Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M. Perera, Cristina R. Ferrone, Edouard Mullarky, Ng Shyh-Chang, Ya’an Kang, Jason B. Fleming, Nabeel Bardeesy, John M. Asara, Marcia C. Haigis, Ronald A. DePinho, Lewis C. Cantley () and Alec C. Kimmelman ()
Additional contact information
Jaekyoung Son: Dana-Farber Cancer Institute
Costas A. Lyssiotis: Harvard Medical School
Haoqiang Ying: University of Texas MD Anderson Cancer Center
Xiaoxu Wang: Dana-Farber Cancer Institute
Sujun Hua: University of Texas MD Anderson Cancer Center
Matteo Ligorio: Massachusetts General Hospital
Rushika M. Perera: Cancer Center, Massachusetts General Hospital
Cristina R. Ferrone: Massachusetts General Hospital
Edouard Mullarky: Harvard Medical School
Ng Shyh-Chang: Harvard Medical School
Ya’an Kang: University of Texas MD Anderson Cancer Center
Jason B. Fleming: University of Texas MD Anderson Cancer Center
Nabeel Bardeesy: Cancer Center, Massachusetts General Hospital
John M. Asara: Beth Israel Deaconess Medical Center
Marcia C. Haigis: Harvard Medical School
Ronald A. DePinho: University of Texas MD Anderson Cancer Center
Lewis C. Cantley: Harvard Medical School
Alec C. Kimmelman: Dana-Farber Cancer Institute

Nature, 2013, vol. 496, issue 7443, 101-105

Abstract: Pancreatic cancers use a novel glutamine metabolism pathway, regulated by oncogenic KRAS, to maintain redox balance; these findings add to the understanding of the mechanisms by which oncogenic alterations reprogram cellular metabolism to promote tumour growth.

Date: 2013
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DOI: 10.1038/nature12040

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