Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M.; Curtis, A. M.; Adamik, J.; Palsson-McDermott, E. M.; McGettrick, A. F.; Goel, G.; Frezza, C.; Bernard, N. J.; Kelly, B.; Foley, N. H.; Zheng, L.; Gardet, A.; Tong, Z.; Jany, S. S.; Corr, S. C.; Haneklaus, M.; Caffrey, B. E.; Pierce, K.; Walmsley, S.; Beasley, F. C.; Cummins, E.; Nizet, V.; Whyte, M.; Taylor, C. T.; Lin, H.; Masters, S. L.; Gottlieb, E.; Kelly, V. P.; Clish, C.; Auron, P. E.; Xavier, R. J.; O’Neill, L. A. J.

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill, A. M. Curtis, J. Adamik, E. M. Palsson-McDermott, A. F. McGettrick, G. Goel, C. Frezza, N. J. Bernard, B. Kelly, N. H. Foley, L. Zheng, A. Gardet, Z. Tong, S. S. Jany, S. C. Corr, M. Haneklaus, B. E. Caffrey, K. Pierce, S. Walmsley, F. C. Beasley, E. Cummins, V. Nizet, M. Whyte, C. T. Taylor, H. Lin, S. L. Masters, E. Gottlieb, V. P. Kelly, C. Clish, P. E. Auron, R. J. Xavier and L. A. J. O’Neill ()
Additional contact information
G. M. Tannahill: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
A. M. Curtis: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
J. Adamik: Duquesne University
E. M. Palsson-McDermott: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
A. F. McGettrick: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
G. Goel: Centre for Computational and Integrative Biology, Massachusetts General Hospital, Richard B. Simches Research Center
C. Frezza: Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
N. J. Bernard: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
B. Kelly: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
N. H. Foley: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
L. Zheng: Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
A. Gardet: The Broad Institute of MIT and Harvard, 7 Cambridge Center
Z. Tong: Cornell University
S. S. Jany: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
S. C. Corr: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
M. Haneklaus: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
B. E. Caffrey: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
K. Pierce: The Broad Institute of MIT and Harvard, 7 Cambridge Center
S. Walmsley: Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield S10 2RX, UK
F. C. Beasley: V. Nizet Laboratory, Centre for Neural Circuits and Behaviour, University of California
E. Cummins: Conway Institute, University College Dublin, Dublin 4, Ireland
V. Nizet: V. Nizet Laboratory, Centre for Neural Circuits and Behaviour, University of California
M. Whyte: Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield S10 2RX, UK
C. T. Taylor: Conway Institute, University College Dublin, Dublin 4, Ireland
H. Lin: Cornell University
S. L. Masters: Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia
E. Gottlieb: Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
V. P. Kelly: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
C. Clish: The Broad Institute of MIT and Harvard, 7 Cambridge Center
P. E. Auron: Duquesne University
R. J. Xavier: Centre for Computational and Integrative Biology, Massachusetts General Hospital, Richard B. Simches Research Center
L. A. J. O’Neill: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

Nature, 2013, vol. 496, issue 7444, 238-242

Abstract: Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation.

Date: 2013
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DOI: 10.1038/nature11986

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