Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

Yoshiki Tanaka, Christopher J. Hipolito, Andrés D. Maturana, Koichi Ito, Teruo Kuroda, Takashi Higuchi, Takayuki Katoh, Hideaki E. Kato, Motoyuki Hattori, Kaoru Kumazaki, Tomoya Tsukazaki, Ryuichiro Ishitani, Hiroaki Suga () and Osamu Nureki ()
Additional contact information
Yoshiki Tanaka: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Christopher J. Hipolito: Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan
Andrés D. Maturana: Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
Koichi Ito: Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan
Teruo Kuroda: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Takashi Higuchi: Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan
Takayuki Katoh: Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan
Hideaki E. Kato: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Motoyuki Hattori: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Kaoru Kumazaki: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Tomoya Tsukazaki: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Ryuichiro Ishitani: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Hiroaki Suga: Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan
Osamu Nureki: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan

Nature, 2013, vol. 496, issue 7444, 247-251

Abstract: Several X-ray crystal structures of an H+-driven multidrug and toxic compound extrusion (MATE) transporter from Pyrococcus furiosus are presented, whose complex structure with macrocyclic peptides may help facilitate the discovery of efficient inhibitors of MATE transporters.

Date: 2013
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DOI: 10.1038/nature12014

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