Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

Billy T. Chen (), Hau-Jie Yau, Christina Hatch, Ikue Kusumoto-Yoshida, Saemi L. Cho, F. Woodward Hopf and Antonello Bonci ()
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Billy T. Chen: Intramural Research Program, National Institute on Drug Abuse
Hau-Jie Yau: Intramural Research Program, National Institute on Drug Abuse
Christina Hatch: Intramural Research Program, National Institute on Drug Abuse
Ikue Kusumoto-Yoshida: Intramural Research Program, National Institute on Drug Abuse
Saemi L. Cho: Ernest Gallo Clinic and Research Center, University of California San Francisco
F. Woodward Hopf: Ernest Gallo Clinic and Research Center, University of California San Francisco
Antonello Bonci: Intramural Research Program, National Institute on Drug Abuse

Nature, 2013, vol. 496, issue 7445, 359-362

Abstract: A study of compulsive drug-seeking behaviour in rats reveals that prolonged cocaine self-administration decreases prelimbic cortex activity resulting in increased compulsive drug-seeking actions; conversely, increasing activity in the prelimbic cortex decreases drug-seeking behaviour, a finding relevant to addiction treatment.

Date: 2013
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DOI: 10.1038/nature12024

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