Visualization of an endogenous retinoic acid gradient across embryonic development

Satoshi Shimozono, Tadahiro Iimura, Tetsuya Kitaguchi, Shin-ichi Higashijima and Atsushi Miyawaki ()
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Satoshi Shimozono: Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
Tadahiro Iimura: Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
Tetsuya Kitaguchi: Life Function and Dynamics, ERATO, JST, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
Shin-ichi Higashijima: National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Aichi, 444-8787, Japan
Atsushi Miyawaki: Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan

Nature, 2013, vol. 496, issue 7445, 363-366

Abstract: Genetically encoded probes for the non-peptidic morphogen retinoic acid allow the quantitative measurement of physiological RA concentration in vivo; the results support the source–sink diffusion model of morphogen dynamics proposed by Francis Crick in 1970.

Date: 2013
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DOI: 10.1038/nature12037

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