A systematic genome-wide analysis of zebrafish protein-coding gene function

Ross N. W. Kettleborough, Elisabeth M. Busch-Nentwich, Steven A. Harvey, Christopher M. Dooley, Ewart de Bruijn, Freek van Eeden, Ian Sealy, Richard J. White, Colin Herd, Isaac J. Nijman, Fruzsina Fényes, Selina Mehroke, Catherine Scahill, Richard Gibbons, Neha Wali, Samantha Carruthers, Amanda Hall, Jennifer Yen, Edwin Cuppen () and Derek L. Stemple ()
Additional contact information
Ross N. W. Kettleborough: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Elisabeth M. Busch-Nentwich: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Steven A. Harvey: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Christopher M. Dooley: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Ewart de Bruijn: Hubrecht Institute, KNAW and University Medical Center Utrecht
Freek van Eeden: The University of Sheffield
Ian Sealy: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Richard J. White: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Colin Herd: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Isaac J. Nijman: Hubrecht Institute, KNAW and University Medical Center Utrecht
Fruzsina Fényes: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Selina Mehroke: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Catherine Scahill: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Richard Gibbons: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Neha Wali: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Samantha Carruthers: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Amanda Hall: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Jennifer Yen: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Edwin Cuppen: Hubrecht Institute, KNAW and University Medical Center Utrecht
Derek L. Stemple: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus

Nature, 2013, vol. 496, issue 7446, 494-497

Abstract: A project to identify the phenotypes of disruptive mutations in every zebrafish protein-coding gene has so far revealed potentially disruptive mutations in more than 38% of the protein-coding genes, and the phenotypic consequences of each allele can be assessed using a novel multi-allelic phenotyping scheme.

Date: 2013
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DOI: 10.1038/nature11992

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