Crystal structure of a eukaryotic phosphate transporter

Bjørn P. Pedersen, Hemant Kumar, Andrew B. Waight, Aaron J. Risenmay, Zygy Roe-Zurz, Bryant H. Chau, Avner Schlessinger, Massimiliano Bonomi, William Harries, Andrej Sali, Atul K. Johri and Robert M. Stroud ()
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Bjørn P. Pedersen: University of California
Hemant Kumar: University of California
Andrew B. Waight: University of California
Aaron J. Risenmay: University of California
Zygy Roe-Zurz: University of California
Bryant H. Chau: University of California
Avner Schlessinger: California Institute for Quantitative Biosciences, University of California
Massimiliano Bonomi: California Institute for Quantitative Biosciences, University of California
William Harries: University of California
Andrej Sali: California Institute for Quantitative Biosciences, University of California
Atul K. Johri: School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
Robert M. Stroud: University of California

Nature, 2013, vol. 496, issue 7446, 533-536

Abstract: The X-ray crystal structure of a high-affinity phosphate importer in an inward-facing, occluded state in the presence of phosphate is reported; this is the first structure of a membrane protein involved in inorganic phosphate uptake and the first crystal structure of a eukaryotic MFS transporter.

Date: 2013
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DOI: 10.1038/nature12042

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