High-level semi-synthetic production of the potent antimalarial artemisinin

C. J. Paddon (), P. J. Westfall, D. J. Pitera, K. Benjamin, K. Fisher, D. McPhee, M. D. Leavell, A. Tai, A. Main, D. Eng, D. R. Polichuk, K. H. Teoh, D. W. Reed, T. Treynor, J. Lenihan, H. Jiang, M. Fleck, S. Bajad, G. Dang, D. Dengrove, D. Diola, G. Dorin, K. W. Ellens, S. Fickes, J. Galazzo, S. P. Gaucher, T. Geistlinger, R. Henry, M. Hepp, T. Horning, T. Iqbal, L. Kizer, B. Lieu, D. Melis, N. Moss, R. Regentin, S. Secrest, H. Tsuruta, R. Vazquez, L. F. Westblade, L. Xu, M. Yu, Y. Zhang, L. Zhao, J. Lievense, P. S. Covello, J. D. Keasling, K. K. Reiling, N. S. Renninger and J. D. Newman ()
Additional contact information
C. J. Paddon: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
P. J. Westfall: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. J. Pitera: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
K. Benjamin: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
K. Fisher: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. McPhee: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
M. D. Leavell: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
A. Tai: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
A. Main: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. Eng: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. R. Polichuk: National Research Council of Canada, 110 Gymnasium Place
K. H. Teoh: National Research Council of Canada, 110 Gymnasium Place
D. W. Reed: National Research Council of Canada, 110 Gymnasium Place
T. Treynor: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
J. Lenihan: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
H. Jiang: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
M. Fleck: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
S. Bajad: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
G. Dang: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. Dengrove: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. Diola: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
G. Dorin: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
K. W. Ellens: National Research Council of Canada, 110 Gymnasium Place
S. Fickes: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
J. Galazzo: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
S. P. Gaucher: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
T. Geistlinger: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
R. Henry: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
M. Hepp: National Research Council of Canada, 110 Gymnasium Place
T. Horning: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
T. Iqbal: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
L. Kizer: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
B. Lieu: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
D. Melis: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
N. Moss: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
R. Regentin: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
S. Secrest: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
H. Tsuruta: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
R. Vazquez: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
L. F. Westblade: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
L. Xu: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
M. Yu: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
Y. Zhang: National Research Council of Canada, 110 Gymnasium Place
L. Zhao: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
J. Lievense: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
P. S. Covello: National Research Council of Canada, 110 Gymnasium Place
J. D. Keasling: University of California
K. K. Reiling: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
N. S. Renninger: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
J. D. Newman: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA

Nature, 2013, vol. 496, issue 7446, 528-532

Abstract: Saccharomyces cerevisiae is engineered to produce high concentrations of artemisinic acid, a precursor of the artemisinin used in combination therapies for malaria treatment; an efficient and practical chemical process to convert artemisinic acid to artemisinin is also developed.

Date: 2013
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DOI: 10.1038/nature12051

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