Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

Myunggon Ko, Jungeun An, Hozefa S. Bandukwala, Lukas Chavez, Tarmo Äijö, William A. Pastor, Matthew F. Segal, Huiming Li, Kian Peng Koh, Harri Lähdesmäki, Patrick G. Hogan, L. Aravind and Anjana Rao ()
Additional contact information
Myunggon Ko: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
Jungeun An: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
Hozefa S. Bandukwala: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
Lukas Chavez: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
Tarmo Äijö: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
William A. Pastor: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
Matthew F. Segal: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
Huiming Li: Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital, Boston, Massachusetts 02115, USA
Kian Peng Koh: Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital, Boston, Massachusetts 02115, USA
Harri Lähdesmäki: Aalto University School of Science
Patrick G. Hogan: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
L. Aravind: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Anjana Rao: La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA

Nature, 2013, vol. 497, issue 7447, 122-126

Abstract: The CXXC domains of TET2 (encoded by the distinct gene IDAX) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent reduction in TET catalytic activity; this regulation is dependent on DNA binding through the CXXC domain.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature12052 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:497:y:2013:i:7447:d:10.1038_nature12052

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12052

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().