Tension sensing by Aurora B kinase is independent of survivin-based centromere localization

Christopher S. Campbell and Arshad Desai ()
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Christopher S. Campbell: University of California San Diego
Arshad Desai: University of California San Diego

Nature, 2013, vol. 497, issue 7447, 118-121

Abstract: The current model to explain accurate chromosome segregation after DNA replication holds that kinetochore–microtubule attachments exert tension across the centromere and are stabilized by spatial separation from inner centromere-localized Aurora B; here an alternative model is presented, wherein active Aurora B produced by clustering is sufficient to ensure biorientation through a mechanism that is intrinsic to the kinetochore.

Date: 2013
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DOI: 10.1038/nature12057

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