Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Muhammed Murtaza, Sarah-Jane Dawson, Dana W. Y. Tsui, Davina Gale, Tim Forshew, Anna M. Piskorz, Christine Parkinson, Suet-Feung Chin, Zoya Kingsbury, Alvin S. C. Wong, Francesco Marass, Sean Humphray, James Hadfield, David Bentley, Tan Min Chin, James D. Brenton (), Carlos Caldas () and Nitzan Rosenfeld ()
Additional contact information
Muhammed Murtaza: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Sarah-Jane Dawson: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Dana W. Y. Tsui: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Davina Gale: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Tim Forshew: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Anna M. Piskorz: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Christine Parkinson: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Suet-Feung Chin: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Zoya Kingsbury: Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK
Alvin S. C. Wong: National University Cancer Institute, National University Health System, 5 Lower Kent Ridge Road, Tower block level 7, 119074 Singapore
Francesco Marass: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Sean Humphray: Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK
James Hadfield: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
David Bentley: Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK
Tan Min Chin: National University Cancer Institute, National University Health System, 5 Lower Kent Ridge Road, Tower block level 7, 119074 Singapore
James D. Brenton: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Carlos Caldas: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Nitzan Rosenfeld: Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK

Nature, 2013, vol. 497, issue 7447, 108-112

Abstract: A proof of principle study shows that by exome sequencing of cell-free circulating DNA from cancer patient plasma samples, the genomic evolution of metastatic cancers and the acquisition of resistance in response to therapy can be tracked over time.

Date: 2013
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DOI: 10.1038/nature12065

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