Extensive transcriptional heterogeneity revealed by isoform profiling

Vicent Pelechano, Wu Wei and Lars M. Steinmetz ()
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Vicent Pelechano: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany
Wu Wei: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany
Lars M. Steinmetz: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany

Nature, 2013, vol. 497, issue 7447, 127-131

Abstract: Variation among RNA transcript isoforms can be generated from alternative start and polyadenylation sites, and results in RNAs and proteins with different properties being generated from the same genomic sequence; here a new method termed transcript isoform sequencing is described in yeast, and the method allows a fuller exploration of transcriptome diversity across the compact yeast genome.

Date: 2013
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DOI: 10.1038/nature12121

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