M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

Noushine Mossadegh-Keller, Sandrine Sarrazin (), Prashanth K. Kandalla, Leon Espinosa, E. Richard Stanley, Stephen L. Nutt, Jordan Moore and Michael H. Sieweke ()
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Noushine Mossadegh-Keller: Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
Sandrine Sarrazin: Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
Prashanth K. Kandalla: Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
Leon Espinosa: Laboratoire de Chimie Bactérienne, Centre National de la Recherche Scientifique, UMR 7283, 31 Chemin Joseph Aiguier, 13009 Marseille, France
E. Richard Stanley: Albert Einstein College of Medicine
Stephen L. Nutt: Walter and Eliza Hall Institute, 1G Royal Parade
Jordan Moore: Fluidigm Corporation
Michael H. Sieweke: Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France

Nature, 2013, vol. 497, issue 7448, 239-243

Abstract: M-CSF, a myeloid cytokine released during infection and inflammation, instructs myeloid lineage fate in single haematopoietic stem cells by directly inducing PU.1, a known myeloid lineage master regulator; this shows that specific cytokines can act directly on haematopoietic stem cells to instruct a change of cell identity.

Date: 2013
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DOI: 10.1038/nature12026

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