A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

Timothy R. Sampson, Sunil D. Saroj, Anna C. Llewellyn, Yih-Ling Tzeng and David S. Weiss ()
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Timothy R. Sampson: Microbiology and Molecular Genetics Program, Emory University
Sunil D. Saroj: Emory University School of Medicine
Anna C. Llewellyn: Microbiology and Molecular Genetics Program, Emory University
Yih-Ling Tzeng: Emory University School of Medicine
David S. Weiss: Emory Vaccine Center, Emory University

Nature, 2013, vol. 497, issue 7448, 254-257

Abstract: The CRISPR/Cas system known to aid bacterial defences by targeting invading DNA can also act to evade eukaryotic defences through a different class of small RNAs downregulating an endogenous immunogenic bacterial lipoprotein.

Date: 2013
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DOI: 10.1038/nature12048

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