Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Anna Cebula, Michal Seweryn, Grzegorz A. Rempala, Simarjot Singh Pabla, Richard A. McIndoe, Timothy L. Denning, Lynn Bry, Piotr Kraj, Pawel Kisielow and Leszek Ignatowicz ()
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Anna Cebula: Center for Biotechnology and Genomic Medicine, Georgia Regents University
Michal Seweryn: Mathematical Biosciences Institute, College of Public Health, Ohio State University
Grzegorz A. Rempala: Mathematical Biosciences Institute, College of Public Health, Ohio State University
Simarjot Singh Pabla: Center for Biotechnology and Genomic Medicine, Georgia Regents University
Richard A. McIndoe: Center for Biotechnology and Genomic Medicine, Georgia Regents University
Timothy L. Denning: Emory University
Lynn Bry: Brigham and Women's Hospital, Harvard Medical School
Piotr Kraj: Center for Biotechnology and Genomic Medicine, Georgia Regents University
Pawel Kisielow: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
Leszek Ignatowicz: Center for Biotechnology and Genomic Medicine, Georgia Regents University

Nature, 2013, vol. 497, issue 7448, 258-262

Abstract: By using high-throughput sequencing of T-cell receptors, this study shows that thymus-derived regulatory T (Treg) cells constitute most Treg cells in all lymphoid and intestinal organs, including the colon, suggesting that thymic Treg cells and not induced Treg cells dominantly control tolerance to the gut’s antigens such as commensal microbiota.

Date: 2013
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DOI: 10.1038/nature12079

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