Security measures of a master regulator
Dario R. Alessi () and
Yogesh Kulathu ()
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Dario R. Alessi: Dario R. Alessi and Yogesh Kulathu are at the MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Yogesh Kulathu: Dario R. Alessi and Yogesh Kulathu are at the MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Nature, 2013, vol. 497, issue 7448, 193-194
Abstract:
At last, the crystal structure is revealed for the catalytically active mTOR kinase enzyme, a master regulator of cell growth. The structure indicates a gatekeeper mechanism that controls substrate access to the active site. See Article p.217
Date: 2013
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DOI: 10.1038/nature12101
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