A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

Hao-Ming Chang, Robinson Triboulet, James E. Thornton and Richard I. Gregory ()
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Hao-Ming Chang: Stem Cell Program, Boston Children’s Hospital
Robinson Triboulet: Stem Cell Program, Boston Children’s Hospital
James E. Thornton: Stem Cell Program, Boston Children’s Hospital
Richard I. Gregory: Stem Cell Program, Boston Children’s Hospital

Nature, 2013, vol. 497, issue 7448, 244-248

Abstract: This study shows that Dis3l2 is the 3′–5′ exonuclease that mediates the degradation of uridylated precursor let-7 microRNA; this is the first physiological RNA substrate identified for this new exonuclease, which causes the Perlman syndrome of fetal overgrowth and Wilms’ tumour susceptibility when mutated.

Date: 2013
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DOI: 10.1038/nature12119

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