Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

Eric J. Benner, Dominic Luciano, Rebecca Jo, Khadar Abdi, Patricia Paez-Gonzalez, Huaxin Sheng, David S. Warner, Chunlei Liu, Cagla Eroglu and Chay T. Kuo ()
Additional contact information
Eric J. Benner: George and Jean Brumley Neonatal-Perinatal Research Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA
Dominic Luciano: Duke University School of Medicine, Durham, North Carolina 27710, USA
Rebecca Jo: George and Jean Brumley Neonatal-Perinatal Research Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA
Khadar Abdi: Duke University School of Medicine, Durham, North Carolina 27710, USA
Patricia Paez-Gonzalez: Duke University School of Medicine, Durham, North Carolina 27710, USA
Huaxin Sheng: Duke University School of Medicine, Durham, North Carolina 27710, USA
David S. Warner: Duke University School of Medicine, Durham, North Carolina 27710, USA
Chunlei Liu: Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, North Carolina 27710, USA
Cagla Eroglu: Duke University School of Medicine, Durham, North Carolina 27710, USA
Chay T. Kuo: George and Jean Brumley Neonatal-Perinatal Research Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA

Nature, 2013, vol. 497, issue 7449, 369-373

Abstract: This paper identifies a specific population of subventricular-zone-generated astrocytes that increases in population density after cortical injury; these activated astrocytes migrate to the site of injury, unlike described properties for their counterparts residing in the cortex.

Date: 2013
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DOI: 10.1038/nature12069

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