EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

Jia Shen, Weiya Xia, Yekaterina B. Khotskaya, Longfei Huo, Kotaro Nakanishi, Seung-Oe Lim, Yi Du, Yan Wang, Wei-Chao Chang, Chung-Hsuan Chen, Jennifer L. Hsu, Yun Wu, Yung Carmen Lam, Brian P. James, Xiuping Liu, Chang-Gong Liu, Dinshaw J. Patel and Mien-Chie Hung ()
Additional contact information
Jia Shen: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Weiya Xia: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Yekaterina B. Khotskaya: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Longfei Huo: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Kotaro Nakanishi: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Seung-Oe Lim: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Yi Du: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Yan Wang: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Wei-Chao Chang: Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University
Chung-Hsuan Chen: Genomics Research Center, Academia Sinica
Jennifer L. Hsu: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Yun Wu: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Yung Carmen Lam: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Brian P. James: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Xiuping Liu: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Chang-Gong Liu: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Mien-Chie Hung: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA

Nature, 2013, vol. 497, issue 7449, 383-387

Abstract: Epidermal growth factor receptor, the product of a human oncogene, suppresses the maturation of specific tumour-suppressor-like microRNAs in response to hypoxic stress through phosphorylation of argonaute 2.

Date: 2013
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DOI: 10.1038/nature12080

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