The shaping and functional consequences of the microRNA landscape in breast cancer

Heidi Dvinge, Anna Git (), Stefan Gräf, Mali Salmon-Divon, Christina Curtis, Andrea Sottoriva, Yongjun Zhao, Martin Hirst, Javier Armisen, Eric A. Miska, Suet-Feung Chin, Elena Provenzano, Gulisa Turashvili, Andrew Green, Ian Ellis, Sam Aparicio () and Carlos Caldas ()
Additional contact information
Heidi Dvinge: University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Anna Git: University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Stefan Gräf: University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Mali Salmon-Divon: European Molecular Biology Laboratory–European Bioinformatics Institute, Wellcome Trust Genome Campus
Christina Curtis: University of Southern California
Andrea Sottoriva: University of Southern California
Yongjun Zhao: Genome Sciences Centre, BC Cancer Agency
Martin Hirst: Genome Sciences Centre, BC Cancer Agency
Javier Armisen: University of Cambridge
Eric A. Miska: University of Cambridge
Suet-Feung Chin: University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Elena Provenzano: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
Gulisa Turashvili: University of British Columbia
Andrew Green: School of Molecular Medical Sciences, University of Nottingham
Ian Ellis: School of Molecular Medical Sciences, University of Nottingham
Sam Aparicio: University of British Columbia
Carlos Caldas: University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK

Nature, 2013, vol. 497, issue 7449, 378-382

Abstract: MicroRNA profiling of 1,302 human breast tumour samples provides an overview of the miRNA landscape and its regulation, revealing context-dependent interactions, broad prognostic value of miRNA signatures and an important modulatory role for miRNAs in the biology of breast tumours devoid of copy-number aberrations.

Date: 2013
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DOI: 10.1038/nature12108

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