Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

Chin Yee Ho, Diana E. Jaalouk, Maria K. Vartiainen and Jan Lammerding ()
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Chin Yee Ho: Cornell University
Diana E. Jaalouk: Brigham and Women’s Hospital/Harvard Medical School
Maria K. Vartiainen: Institute of Biotechnology, University of Helsinki
Jan Lammerding: Cornell University

Nature, 2013, vol. 497, issue 7450, 507-511

Abstract: Lamin and emerin mutations causing cardiomyopathies are associated with an impairment in actin dynamics, resulting in aberrant nuclear translocation and downstream signalling of the transcription factor MKL1, which is pivotal for cardiac development.

Date: 2013
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DOI: 10.1038/nature12105

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