Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

Jia Zhu (), Tao Peng, Christine Johnston, Khamsone Phasouk, Angela S. Kask, Alexis Klock, Lei Jin, Kurt Diem, David M. Koelle, Anna Wald, Harlan Robins and Lawrence Corey ()
Additional contact information
Jia Zhu: University of Washington
Tao Peng: Fred Hutchinson Cancer Research Center
Christine Johnston: University of Washington
Khamsone Phasouk: Fred Hutchinson Cancer Research Center
Angela S. Kask: University of Washington
Alexis Klock: University of Washington
Lei Jin: University of Washington
Kurt Diem: University of Washington
David M. Koelle: University of Washington
Anna Wald: University of Washington
Harlan Robins: Program in Computational Biology, Fred Hutchinson Cancer Research Center
Lawrence Corey: University of Washington

Nature, 2013, vol. 497, issue 7450, 494-497

Abstract: Herpes simplex virus 2-infected individuals are shown to have skin-tissue-resident CD8αα+ T cells that persist at the portal of virus release in genital skin and mucosa, possess oligoclonal T-cell-receptor-β CDR3 sequences that are stable over time, and express gene signatures of antiviral and cytolytic function indicative of viral-specific immune surveillance.

Date: 2013
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DOI: 10.1038/nature12110

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