Sema3A regulates bone-mass accrual through sensory innervations

Toru Fukuda, Shu Takeda (), Ren Xu, Hiroki Ochi, Satoko Sunamura, Tsuyoshi Sato, Shinsuke Shibata, Yutaka Yoshida, Zirong Gu, Ayako Kimura, Chengshan Ma, Cheng Xu, Waka Bando, Koji Fujita, Kenichi Shinomiya, Takashi Hirai, Yoshinori Asou, Mitsuhiro Enomoto, Hideyuki Okano, Atsushi Okawa and Hiroshi Itoh
Additional contact information
Toru Fukuda: School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Shu Takeda: School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Ren Xu: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Hiroki Ochi: School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Satoko Sunamura: School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Tsuyoshi Sato: Saitama Medical University, Morohongo 38, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan
Shinsuke Shibata: School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Yutaka Yoshida: Cincinnati Children's Hospital Medical Center
Zirong Gu: Cincinnati Children's Hospital Medical Center
Ayako Kimura: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Chengshan Ma: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Cheng Xu: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Waka Bando: Section of Nephrology, Endocrinology and Metabolism, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Koji Fujita: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Kenichi Shinomiya: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Takashi Hirai: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Yoshinori Asou: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Mitsuhiro Enomoto: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Hideyuki Okano: School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan
Atsushi Okawa: Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
Hiroshi Itoh: Section of Nephrology, Endocrinology and Metabolism, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan

Nature, 2013, vol. 497, issue 7450, 490-493

Abstract: Sema3A, a member of the semaphorin family of proteins, is shown to regulate bone remodelling indirectly by modulating sensory nerve development in mice.

Date: 2013
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DOI: 10.1038/nature12115

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