The TLR4 antagonist Eritoran protects mice from lethal influenza infection

Kari Ann Shirey, Wendy Lai, Alison J. Scott, Michael Lipsky, Pragnesh Mistry, Lioubov M. Pletneva, Christopher L. Karp, Jaclyn McAlees, Theresa L. Gioannini, Jerrold Weiss, Wilbur H. Chen, Robert K. Ernst, Daniel P. Rossignol, Fabian Gusovsky, Jorge C. G. Blanco and Stefanie N. Vogel ()
Additional contact information
Kari Ann Shirey: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Wendy Lai: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Alison J. Scott: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Michael Lipsky: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Pragnesh Mistry: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Lioubov M. Pletneva: Sigmovir Biosystems, Inc.
Christopher L. Karp: Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Jaclyn McAlees: Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Theresa L. Gioannini: The Inflammation Program, University of Iowa
Jerrold Weiss: The Inflammation Program, University of Iowa
Wilbur H. Chen: Center for Vaccine Development, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Robert K. Ernst: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
Daniel P. Rossignol: Eisai, Inc.
Fabian Gusovsky: Eisai, Inc.
Jorge C. G. Blanco: Sigmovir Biosystems, Inc.
Stefanie N. Vogel: University of Maryland, Baltimore, Baltimore, Maryland 21201, USA

Nature, 2013, vol. 497, issue 7450, 498-502

Abstract: TLR4 stimulation is known to contribute to acute lung injury after administration of inactivated influenza virus; here, the synthetic TLR4 antagonist Eritoran is shown to protect mice from death after infection with a lethal dose of the virus.

Date: 2013
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DOI: 10.1038/nature12118

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