Pif1 family helicases suppress genome instability at G-quadruplex motifs

Katrin Paeschke, Matthew L. Bochman, P. Daniela Garcia, Petr Cejka, Katherine L. Friedman, Stephen C. Kowalczykowski and Virginia A. Zakian ()
Additional contact information
Katrin Paeschke: Princeton University
Matthew L. Bochman: Princeton University
P. Daniela Garcia: Princeton University
Petr Cejka: and Molecular and Cellular Biology, University of California
Katherine L. Friedman: Vanderbilt University
Stephen C. Kowalczykowski: and Molecular and Cellular Biology, University of California
Virginia A. Zakian: Princeton University

Nature, 2013, vol. 497, issue 7450, 458-462

Abstract: Abstract The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Moreover, Pif1 helicases from organisms separated by more than 3 billion years of evolution suppressed DNA damage at G-quadruplex motifs in yeast. The G-quadruplex-induced damage generated in the absence of Pif1 helicases led to new genetic and epigenetic changes. Furthermore, when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening.

Date: 2013
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DOI: 10.1038/nature12149

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