Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso, Shawn M. Davidson, Rengin G. Soydaner-Azeloglu, Seth J. Parker, Jurre J. Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A. Drebin, Craig B. Thompson, Joshua D. Rabinowitz, Christian M. Metallo, Matthew G. Vander Heiden and Dafna Bar-Sagi ()
Additional contact information
Cosimo Commisso: New York University School of Medicine
Shawn M. Davidson: Massachusetts Institute of Technology
Rengin G. Soydaner-Azeloglu: New York University School of Medicine
Seth J. Parker: University of California, San Diego, La Jolla, California 92093, USA
Jurre J. Kamphorst: Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University
Sean Hackett: Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University
Elda Grabocka: New York University School of Medicine
Michel Nofal: Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University
Jeffrey A. Drebin: Hospital of the University of Pennsylvania
Craig B. Thompson: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center
Joshua D. Rabinowitz: Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University
Christian M. Metallo: University of California, San Diego, La Jolla, California 92093, USA
Matthew G. Vander Heiden: Massachusetts Institute of Technology
Dafna Bar-Sagi: New York University School of Medicine

Nature, 2013, vol. 497, issue 7451, 633-637

Abstract: Oncogenic Ras has previously been shown to promote macropinocytosis; here it is demonstrated that this process allows tumour cells to use extracellular proteins to generate amino acids necessary to support tumour growth.

Date: 2013
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DOI: 10.1038/nature12138

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