Synthetic analog computation in living cells

Ramiz Daniel, Jacob R. Rubens, Rahul Sarpeshkar () and Timothy K. Lu ()
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Ramiz Daniel: Analog Circuits and Biological Systems Group, Research Lab of Electronics, Massachusetts Institute of Technology
Jacob R. Rubens: Synthetic Biology Group, Research Lab of Electronics, Massachusetts Institute of Technology
Rahul Sarpeshkar: Analog Circuits and Biological Systems Group, Research Lab of Electronics, Massachusetts Institute of Technology
Timothy K. Lu: Synthetic Biology Group, Research Lab of Electronics, Massachusetts Institute of Technology

Nature, 2013, vol. 497, issue 7451, 619-623

Abstract: Synthetic analog gene circuits can be engineered to execute logarithmically linear sensing, addition, ratiometric and power-law computations in living cells using just three transcription factors.

Date: 2013
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DOI: 10.1038/nature12148

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