Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

Timothy A. Sanders, Esther Llagostera and Maria Barna ()
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Timothy A. Sanders: University of California San Francisco
Esther Llagostera: University of California San Francisco
Maria Barna: University of California San Francisco

Nature, 2013, vol. 497, issue 7451, 628-632

Abstract: This study uses single-cell real-time imaging to show that sonic hedgehog (SHH) is produced in the form of a particle that is transported along a novel class of specialized actin-based filopodia spanning several cell diameters within the field of SHH cell signalling, thus expanding our knowledge of ligand movement during normal vertebrate development.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:497:y:2013:i:7451:d:10.1038_nature12157

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DOI: 10.1038/nature12157

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