Breen et al. reply

Michael S. Breen, Carsten Kemena, Peter K. Vlasov, Cedric Notredame and Fyodor A. Kondrashov ()
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Michael S. Breen: University of California San Diego
Carsten Kemena: †Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
Peter K. Vlasov: †Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
Cedric Notredame: †Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
Fyodor A. Kondrashov: †Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain

Nature, 2013, vol. 497, issue 7451, E2-E3

Abstract: Abstract replying to D. M. McCandlish, E. Rajon, P. Shah, Y. Ding & J. B. Plotkin Nature 497, 10.1038/nature12219 (2013) Understanding fitness landscapes, a conceptual depiction of the genotype-to-phenotype relationship, is crucial to many areas of biology. Two aspects of fitness landscapes are the focus of contemporary studies of molecular evolution. First, the local shape of the fitness landscape defined by the contribution of individual alleles to fitness that is independent of all genetic interactions. Second, the global, multidimensional fitness landscape1 shape determined by how interactions between alleles at different loci change each other’s fitness impact, or epistasis. In explaining the high amino-acid usage (u), we focused on the global shape of the fitness landscape2, ignoring the perturbations at individual sites3.

Date: 2013
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DOI: 10.1038/nature12220

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