Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

Jungwook Kim (), Hui Xiao, Jeffrey B. Bonanno, Chakrapani Kalyanaraman, Shoshana Brown, Xiangying Tang, Nawar F. Al-Obaidi, Yury Patskovsky, Patricia C. Babbitt, Matthew P. Jacobson, Young-Sam Lee and Steven C. Almo ()
Additional contact information
Jungwook Kim: Albert Einstein College of Medicine
Hui Xiao: Albert Einstein College of Medicine
Jeffrey B. Bonanno: Albert Einstein College of Medicine
Chakrapani Kalyanaraman: University of California at San Francisco
Shoshana Brown: University of California at San Francisco
Xiangying Tang: Albert Einstein College of Medicine
Nawar F. Al-Obaidi: Albert Einstein College of Medicine
Yury Patskovsky: Albert Einstein College of Medicine
Patricia C. Babbitt: University of California at San Francisco
Matthew P. Jacobson: University of California at San Francisco
Young-Sam Lee: Johns Hopkins University
Steven C. Almo: Albert Einstein College of Medicine

Nature, 2013, vol. 498, issue 7452, 123-126

Abstract: Members of the SAM-dependent methyltransferase superfamily are involved in the modification of wobble uridine to 5-oxacetyl uridine in Gram-negative bacteria; CmoA converts SAM to carboxy-SAM (Cx-SAM; a metabolite that was unknown previously), and CmoB uses Cx-SAM to convert 5-hydroxyuridine to 5-oxyacetyl uridine in tRNA.

Date: 2013
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DOI: 10.1038/nature12180

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