EconPapers    
Economics at your fingertips  
 

Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

Jungwook Kim (), Hui Xiao, Jeffrey B. Bonanno, Chakrapani Kalyanaraman, Shoshana Brown, Xiangying Tang, Nawar F. Al-Obaidi, Yury Patskovsky, Patricia C. Babbitt, Matthew P. Jacobson, Young-Sam Lee and Steven C. Almo ()
Additional contact information
Jungwook Kim: Albert Einstein College of Medicine
Hui Xiao: Albert Einstein College of Medicine
Jeffrey B. Bonanno: Albert Einstein College of Medicine
Chakrapani Kalyanaraman: University of California at San Francisco
Shoshana Brown: University of California at San Francisco
Xiangying Tang: Albert Einstein College of Medicine
Nawar F. Al-Obaidi: Albert Einstein College of Medicine
Yury Patskovsky: Albert Einstein College of Medicine
Patricia C. Babbitt: University of California at San Francisco
Matthew P. Jacobson: University of California at San Francisco
Young-Sam Lee: Johns Hopkins University
Steven C. Almo: Albert Einstein College of Medicine

Nature, 2013, vol. 498, issue 7452, 123-126

Abstract: Members of the SAM-dependent methyltransferase superfamily are involved in the modification of wobble uridine to 5-oxacetyl uridine in Gram-negative bacteria; CmoA converts SAM to carboxy-SAM (Cx-SAM; a metabolite that was unknown previously), and CmoB uses Cx-SAM to convert 5-hydroxyuridine to 5-oxyacetyl uridine in tRNA.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature12180 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12180

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12180

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().

 
Page updated 2025-03-19
Handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12180