Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

Matthew R. Hepworth, Laurel A. Monticelli, Thomas C. Fung, Carly G. K. Ziegler, Stephanie Grunberg, Rohini Sinha, Adriana R. Mantegazza, Hak-Ling Ma, Alison Crawford, Jill M. Angelosanto, E. John Wherry, Pandelakis A. Koni, Frederic D. Bushman, Charles O. Elson, Gérard Eberl, David Artis and Gregory F. Sonnenberg ()
Additional contact information
Matthew R. Hepworth: Perelman School of Medicine, University of Pennsylvania
Laurel A. Monticelli: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Thomas C. Fung: Perelman School of Medicine, University of Pennsylvania
Carly G. K. Ziegler: ImmunoDynamics Group, Programs in Computational Biology and Immunology, Memorial Sloan-Kettering Cancer Center
Stephanie Grunberg: Perelman School of Medicine, University of Pennsylvania
Rohini Sinha: Perelman School of Medicine, University of Pennsylvania
Adriana R. Mantegazza: Perelman School of Medicine, University of Pennsylvania
Hak-Ling Ma: Inflammation and Immunology Research Unit, Biotherapeutics Research and Development, Pfizer Worldwide R&D, Cambridge, Massachusetts 02140, USA
Alison Crawford: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Jill M. Angelosanto: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
E. John Wherry: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Pandelakis A. Koni: Cancer Immunology, Inflammation & Tolerance Program, Georgia Health Sciences University Cancer Center
Frederic D. Bushman: Perelman School of Medicine, University of Pennsylvania
Charles O. Elson: University of Alabama at Birmingham
Gérard Eberl: Lymphoid Tissue Development Unit, Institute Pasteur, 75724 Paris, France
David Artis: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Gregory F. Sonnenberg: Perelman School of Medicine, University of Pennsylvania

Nature, 2013, vol. 498, issue 7452, 113-117

Abstract: Group 3 innate lymphoid cells are shown to process and present antigen and to control CD4+ T-cell responses to intestinal commensal bacteria through an MHC-class-II-dependent mechanism.

Date: 2013
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DOI: 10.1038/nature12240

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