Chromosome-specific nonrandom sister chromatid segregation during stem-cell division

Swathi Yadlapalli () and Yukiko M. Yamashita ()
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Swathi Yadlapalli: Life Sciences Institute, Center for Stem Cell Biology, University of Michigan
Yukiko M. Yamashita: Life Sciences Institute, Center for Stem Cell Biology, University of Michigan

Nature, 2013, vol. 498, issue 7453, 251-254

Abstract: Using a CO-FISH method with single-chromosome resolution, sister chromatids of the sex chromosomes, but not autosomes, are shown to segregate nonrandomly during asymmetric cell divisions of Drosophila male germline stem cells; this suggests that it is unlikely that nonrandom sister chromatid segregation serves to protect the ‘immortal strand’ to avoid replication-induced mutations as proposed previously.

Date: 2013
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DOI: 10.1038/nature12106

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