RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

John R. Lukens, Peter Vogel, Gordon R. Johnson, Michelle A. Kelliher, Yoichiro Iwakura, Mohamed Lamkanfi and Thirumala-Devi Kanneganti ()
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John R. Lukens: St Jude Children’s Research Hospital
Peter Vogel: Animal Resources Center and the Veterinary Pathology Core, St Jude Children’s Research Hospital
Gordon R. Johnson: St Jude Children’s Research Hospital
Michelle A. Kelliher: University of Massachusetts Medical School
Yoichiro Iwakura: Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
Mohamed Lamkanfi: VIB, B-9000 Ghent, Belgium
Thirumala-Devi Kanneganti: St Jude Children’s Research Hospital

Nature, 2013, vol. 498, issue 7453, 224-227

Abstract: This study defines a novel RIP1-kinase- and IL-1α-dependent autoinflammatory pathway that depends on NF-κB and is controlled by the tyrosine phosphatase SHP-1.

Date: 2013
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DOI: 10.1038/nature12174

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