Vector transmission regulates immune control of Plasmodium virulence

Philip J. Spence, William Jarra, Prisca Lévy, Adam J. Reid, Lia Chappell, Thibaut Brugat, Mandy Sanders, Matthew Berriman and Jean Langhorne ()
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Philip J. Spence: MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK
William Jarra: MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK
Prisca Lévy: MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK
Adam J. Reid: Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Lia Chappell: Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Thibaut Brugat: MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK
Mandy Sanders: Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Matthew Berriman: Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Jean Langhorne: MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK

Nature, 2013, vol. 498, issue 7453, 228-231

Abstract: Serial passage of the malaria parasite through rodents, primates or human hosts increases parasite virulence, suggesting that vector transmission regulates virulence, although direct evidence for this has been lacking; mosquito transmission is shown here to intrinsically modify asexual blood-stage Plasmodium chabaudi chabaudi, which elicits altered host immune responses that, in turn, modify disease severity.

Date: 2013
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DOI: 10.1038/nature12231

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