MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

Hong Han, Manuel Irimia, P. Joel Ross, Hoon-Ki Sung, Babak Alipanahi, Laurent David, Azadeh Golipour, Mathieu Gabut, Iacovos P. Michael, Emil N. Nachman, Eric Wang, Dan Trcka, Tadeo Thompson, Dave O’Hanlon, Valentina Slobodeniuc, Nuno L. Barbosa-Morais, Christopher B. Burge, Jason Moffat, Brendan J. Frey, Andras Nagy, James Ellis, Jeffrey L. Wrana and Benjamin J. Blencowe ()
Additional contact information
Hong Han: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Manuel Irimia: University of Toronto, Toronto, Ontario M5S 3E1, Canada
P. Joel Ross: Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Hoon-Ki Sung: Center for Stem Cells and Tissue Engineering, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Babak Alipanahi: University of Toronto, Toronto, Ontario M5S 3G4, Canada
Laurent David: Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Azadeh Golipour: University of Toronto, Toronto, Ontario M5S 1A8, Canada
Mathieu Gabut: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Iacovos P. Michael: Center for Stem Cells and Tissue Engineering, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Emil N. Nachman: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Eric Wang: Massachusetts Institute of Technology
Dan Trcka: Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Tadeo Thompson: Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Dave O’Hanlon: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Valentina Slobodeniuc: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Nuno L. Barbosa-Morais: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Christopher B. Burge: Massachusetts Institute of Technology
Jason Moffat: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Brendan J. Frey: University of Toronto, Toronto, Ontario M5S 3E1, Canada
Andras Nagy: Center for Stem Cells and Tissue Engineering, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
James Ellis: University of Toronto, Toronto, Ontario M5S 1A8, Canada
Jeffrey L. Wrana: University of Toronto, Toronto, Ontario M5S 1A8, Canada
Benjamin J. Blencowe: University of Toronto, Toronto, Ontario M5S 3E1, Canada

Nature, 2013, vol. 498, issue 7453, 241-245

Abstract: This study identifies MBNL proteins as negative regulators of alternative splicing events that are differentially regulated between ES cells and other cell types; several lines of evidence show that these proteins repress an ES cell alternative splicing program and the reprogramming of somatic cells to induced pluripotent stem cells.

Date: 2013
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DOI: 10.1038/nature12270

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