Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Tim Lämmermann (), Philippe V. Afonso, Bastian R. Angermann, Ji Ming Wang, Wolfgang Kastenmüller, Carole A. Parent and Ronald N. Germain ()
Additional contact information
Tim Lämmermann: Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Philippe V. Afonso: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Bastian R. Angermann: Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Ji Ming Wang: Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Wolfgang Kastenmüller: Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Carole A. Parent: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Ronald N. Germain: Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature, 2013, vol. 498, issue 7454, 371-375

Abstract: Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue injury and infection; leukotriene B4 (LTB4) is shown to act between neutrophils as a signal relay molecule that acts to enhance the radius of neutrophil recruitment within the inflamed interstitium, and also to control, in concert with integrin receptors, dense neutrophil clustering for tight wound seal formation.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature12175 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:498:y:2013:i:7454:d:10.1038_nature12175

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12175

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().