Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1

Julie A. Law, Jiamu Du, Christopher J. Hale, Suhua Feng, Krzysztof Krajewski, Ana Marie S. Palanca, Brian D. Strahl, Dinshaw J. Patel () and Steven E. Jacobsen ()
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Julie A. Law: Cell and Developmental Biology, University of California at Los Angeles
Jiamu Du: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Christopher J. Hale: Cell and Developmental Biology, University of California at Los Angeles
Suhua Feng: Cell and Developmental Biology, University of California at Los Angeles
Krzysztof Krajewski: University of North Carolina at Chapel Hill
Ana Marie S. Palanca: Plant Molecular and Cellular Biology, Salk Institute
Brian D. Strahl: University of North Carolina at Chapel Hill
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Steven E. Jacobsen: Cell and Developmental Biology, University of California at Los Angeles

Nature, 2013, vol. 498, issue 7454, 385-389

Abstract: In Arabidopsis, RNA-directed DNA methylation is a poorly understood gene silencing pathway in which small interfering RNAs generated by RNA polymerase IV (Pol-IV) target a DNA methyltransferase to its sites of action; here structural and genomic analyses demonstrate that SHH binds chromatin via repressive histone modifications and recruits Pol-IV to enable siRNA production.

Date: 2013
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DOI: 10.1038/nature12178

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